NBDF funds a broad range of research programs that seek to increase our understanding of the science behind bleeding disorders, how they affect people's lives, and pathways to better treatments and cures.
Immunology of Liver-Derived Expression of Factor IX from AAV Vectors
Year:
-
Grants:
Career Development Award
Hemophilia B (Factor IX/F9)
Gene Therapy
Correction of Hemophilia with Lentiviral Vectors
Year:
-
Grants:
Career Development Award
Hemophilia A (Factor VIII/F8)
Hemophilia B (Factor IX/F9)
Gene Therapy
Development and Characterization of Novel Genetically Engineered Factor VIII Molecules with Increased Activity and Stability
Year:
-
Grants:
Career Development Award
Hemophilia A (Factor VIII/F8)
Treatment of a Mouse Model of Hemophilia Using AAV Vectors Expressing Murine Factor VIII
Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia A (Factor VIII/F8)
Gene Therapy
Induction of Immune Tolerance to Factor IX
Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia B (Factor IX/F9)
Inhibitors
Vascular Bed-Specific Regulation of the VWF Gene
Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Von Willebrand Disease
New Therapeutics for Hepatitis C
Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hepatitis/Liver Disease
Mechanisms Involved in Transduction of Human Lentivirus in Liver: A Strategy for Hemophilia Gene Therapy
Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Gene Therapy
Hemophilia A (Factor VIII/F8)
Hemophilia B (Factor IX/F9)
T Cell Epitopes on Factor VIII
Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia A (Factor VIII/F8)
HIV/AIDS
AAV Hemophilia Gene Therapy Vectors
Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Gene Therapy
Hemophilia A (Factor VIII/F8)
Hemophilia B (Factor IX/F9)
Impact of VWF on Factor VIII Gene Targeting
Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Von Willebrand Disease
Hemophilia A (Factor VIII/F8)
Vitamin K-Dependent Carboxylase (1997)
Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Vitamin K
Factor VIII Delivery via Skin
Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia A (Factor VIII/F8)
Vitamin K-Dependent Carboxylase (1996)
Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Vitamin K
Interaction of Factor VIII with Factor IXa
Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia A (Factor VIII/F8)
Hemophilia B (Factor IX/F9)
Persistent Expression of Factor IX
Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia B (Factor IX/F9)
Gene Therapy for Hemophilia B
Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Gene Therapy
Hemophilia B (Factor IX/F9)
HIV Resistance in Hemophiliacs
Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
HIV/AIDS
Hemophilia A (Factor VIII/F8)
Hemophilia B (Factor IX/F9)
Per Dr. Tenenbaum, the JGP provided him with the necessary framework to complete his Postdoctoral Fellowship at Duke University Medical Center and his first academic position at SUNY, where he is currently a Professor specializing in RNA Nanotechnology and Genomics. Although he has not remained in the field of hematology, his current research does intersect with many diseases, including those in the field of hematology (and specifically, hemophilia). The intersection is in relation to gene therapy technology that he is developing.
Factor VIII Gene Therapy Vectors
Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Gene Therapy
Hemophilia A (Factor VIII/F8)
Factor VIII–Specific T Lymphocytes
Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia A (Factor VIII/F8)
HIV/AIDS
Per Dr. Singer, the JGP greatly influenced her career in research. It allowed her to focus on a research project, understand the process of asking a question/creating a hypothesis and developing (with guidance) a research plan; as well as analyze the date, present it (at NHG meeting at ASH) and write/publish it. It sparked her interest in hematology and in clinical research. She has pursued her work in the field of Pediatric Hematology and has obtained funding for research (including a K23 award). She has continued with ‘benign hematology’, focusing on Thalassemia (clinical and clinical research), as well as general hematology and hemostasis. Recently, she has become more involved in hemostasis (clinical care and sponsored studies related to bleeding/thrombosis).