NBDF funds a broad range of research programs that seek to increase our understanding of the science behind bleeding disorders, how they affect people's lives, and pathways to better treatments and cures.
Gene Therapy for Hemophilia A and B
Vitamin K-Dependent Carboxylase (1991)
Gene Therapy of Hemophilia B
Genetics of Type I/ III von Willebrand Disease
Replacement of the Factor IX Gene in a Canine Hemophilia B Model
Molecular and Cell Biology on von Willebrand Factor Variants
Carbohydrate and Carbohydrate Sulfation in the Structure and Function of von Willebrand Factor
Characterization of Gene Defects in Hemophilia A
The Molecular Biology of Canine Hemophilia B
von Willebrand Disease: Molecular Studies in the Porcine Model
Mechanisms of Retroviral Integration Recombination
Per Dr. Katzman, the Judith Graham Pool Research Fellowship in Hemophilia from the National Hemophilia Foundation, that he received in 1986, was extremely formative. This initial support was the starting point that led to 25 years of productive research in HIV/AIDS, during which he believes he made significant contributions to understanding the mechanism of retrovirus integration (and the introduction of integrase inhibitors into clinical practice for treating HIV infection was particularly gratifying). The JGP Fellowship allowed him to transition during his Infectious Diseases Fellowship in a new direction. Having worked with Dr. Michael Lederman in the Department of Medicine at Case Western Reserve University and University Hospitals of Cleveland for two years on the immune dysfunction in HIV-infected hemophiliacs, this grant allowed him to enter the basic science laboratory of Jonathan Leis in the Department of Biochemistry, where he remained for 3 years in what — in essence — was a 5-year Fellowship in Infectious Diseases. Having gained this extra training, he was then prepared to obtain an independent faculty position and he moved to the Milton S. Hershey Medical Center and Penn State College of Medicine in the Departments of Medicine and Microbiology & Immunology in 1989. He continues in this faculty position, where he has combined basic research on retroviral integration with the clinical care of persons with HIV and other infectious Diseases, though he did close his basic science lab at the end of 2011. A description of his research and career record is available at: https://profiles.psu.edu/profiles/display/111718
The Role of Hepatitis B and Hepatitis Delta Virus as Cofactors in the Acquired Immunodeficiency Syndrome in a Hemophilia Population
Studies in Fibrinolysis: Human Endothelial Cells in Culture and In Vivo Studies in Hemophilia
Modulation of Plasminogen Activator and Plasminogen Activator from Human Endothelial Cells
DNA Analysis of the Factor IX Gene and the Role of B-Hydroxyaspartic Acid in the Vitamin K-Dependent Coagulation Factor
DNA Analysis of the Factor IX Gene from a Patient with Hemophilia B
Characterization of Intermediates and Products of the Factor Xa-Catalyzed Activation of Factor V
Functional Characterization of the Carboxy-Terminal Domain of Human Factor IX
Studies in Factor VIII: Effects of Commercial Preparations of Antihemophilic Factor in Immunocompetent Cell Populations
